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Good levels of serotonin induce feelings of contentment, reduce appetite and improve sleep. It’s this understanding of serotonin that led to the development of antidepressants known as SSRIs (selective serotonin reuptake inhibitors).

This had been explained partly by social factors — women are more likely to seek help for their symptoms compared with men.

However, a recent study from Sweden has discovered two key differences in the way men and women’s brains process serotonin, the so-called ‘happy hormone’.

They are self-medicating with carbohydrates to raise their serotonin to stave off the grumps.

The most effective way to boost tryptophan in the brain is to eat carbohydrate foods, which stimulate the release of insulin.

First, you should talk to your GP, as mild antidepressants may help.

If they are considered inappropriate, lifestyle changes can help, as stress, poor diet and a lack of exercise (and even a lack of sunlight) are all thought to deplete serotonin.

These are the cellular equivalent of motorway service stations, where you can refuel your cells.